After five heart surgeries I found myself depressed with anxiety and panic attacks. I was at my wits-end and was ready to clean my system up from depression meds and go the "natural" way. My husband and I put a lot of research into finding these supplements and it was a lot of trial-n-error. We took into account pricing and budget, as well as, purity of the ingredients. All of these supplements have worked for my family and I hope they help you too!